不同的手術鑽頭程序對於有全雷射微溝槽植體表面的影響-綿羊的實驗研究

The effect of different surgical drilling procedures on full laser-etched microgrooves surface-treated implants: an experimental study in sheep


作者：Jimbo R, Tovar N, Yoo DY, Janal MN, Anchieta RB, Coelho PG.
出處：Clin Oral Implants Res. 2014 Sep; 25(9): 1072-7

 

OBJECTIVES 目的
 
To evaluate the influence of instrumentation technique on the early osseointegration histomorphometrics and biomechanical fixation of fully laseretched microgrooves implant surfaces in a sheep model.  
以綿羊為受試者，植入全雷射微溝槽表面處理的植體，再以儀器評估早期骨整合的組織型態和生物力學固定的影響。
 
Materials and Methods: 材料和方法
 
Six sheep were subjected to bilateral hip surgeries 3 and 6 weeks before euthanasia. A total of 48 implants (∅4.5 mm, 8 mm in length) were distributed among four sites (8 per animal) and placed in bone sites drilled to 4.6 mm (reamer), 4.1 mm (loose), 3.7 mm (medium) and 3.2 mm (tight) in diameter. After healing, the animals were euthanized and half of the implants were biomechanically tested, while the remainder was subjected to non-decalcified histologic processing. The histomorphometric parameters assessed were bone-toimplant contact (BIC) and bone area fraction occupancy (BAFO). Statistical analysis was performed using a mixed model analysis of variance with significance level set at P < 0.05.
六隻綿羊安樂死前的三到六週，進行雙側髖關節手術。共有48支植體(直徑4.5mm，長8mm)分佈在4個部位(每隻動物各植入8支植體)中，並放置在鑽孔直徑4.6mm(擴孔器)，4.1 mm（鬆散），3.7 mm（中等）和 3.2毫米（緊）的骨骼部位。癒合後，將動物安樂死並對一半植入物進行生物力學測試，而其餘的進行非脫鈣組織學處理。評估骨頭與植體接觸面積(BIC)和骨面積佔據分數(BAFO)的組織型態學參數。進行混合受試分差的統計學分析，顯著性水平設定為P<0.05。
 
Results: 結果 
 
A general increasing trend is present from 3 to 6 weeks for most of the variables. The groups prepared to be press fit seemed to present higher values, which were maintained throughout the observation period. The reamer group presented the lowest BIC probably due to the drilling technique; however qualitatively, more new bone seemed to be in contact to the implant surface, at 3 weeks, whereas the implants placed in press-fit situations were mainly supported by cortical bone.
對於大多數的變量，一般增加的趨勢為3至6週。準備組在受壓下似乎呈現高值，而在整個觀察期內是保持不變的。擴孔組可能由於鑽孔技術而呈現出最低的BIC；然而，定性地，在3週時，更多的新骨似乎與植入物表面接觸，而在受壓的情況下，植入的植體主要是由皮質骨所支撐。
 
Conclusion:結論 
 
The laser-etched microgrooved implant presented osteoconductive and biocompatible properties for all surgical procedures tested. However, procedures providing increasingly higher press-fit scenarios presented the strongest histomorphometric and biomechanical responses at 3 and 6 weeks.
具有雷射微溝槽的植體對於所有手術過程的測試提供了骨傳導和生物相容性。然而，在提供高壓的受試下，3和6週呈現出最強的組織學型態和生物力學反應。
 

 

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