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美國植體品牌 - Interactions between MC3T3-E1 cells and textured Ti6Al4V surfaces

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學術文章：
Interactions between MC3T3-E1 cells and textured Ti6Al4V surfaces.

作者：Soboyejo WO, Nemetski B, Allameh S, Marcantonio N, Mercer C, Ricci J.
出處：J Biomed Mater Res. 2002 Oct; 62(1):56-72

摘要：
ABSTRACT

This paper presents the results of an experimental study of the interactions between MC3T3-E1 (mouse calvarian) cells and textured Ti6Al4V surfaces, including surfaces produced by laser microgrooving; blasting with alumina particles; and polishing. The multiscale interactions between MC3T3-E1 cells and these textured surfaces are studied using a combination of optical scanning transmission electron microscopy and atomic force microscopy. The potential cytotoxic effects of microchemistry on cell-surface interactions also are considered in studies of cell spreading and orientation over 9-day periods. These studies show that cells on microgrooved Ti6Al4V geometries that are 8 or 12 micron deep undergo contact guidance and limited cell spreading. Similar contact guidance is observed on the surfaces of diamond-polished surfaces on which nanoscale grooves are formed due to the scratching that occurs during polishing. In contrast, random cell orientations are observed on alumina-blasted Ti6Al4V surfaces. The possible effects of surface topography are discussed for scar-tissue formation and improved cell-surface integration

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